May 02, 2007. The FDA gives green light to Perlane (Medicis Aesthetics Holdings Inc.) to sell their anti-wrinkle therapy here in the states. Perlane has been used for years in Europe (and even illegally here in the US as doctors import it over for use in their patients). Perlane is comparable to collagen and Botox injection.

Botox is widely used today, becoming a household name and even have Botox parties reminiscent of the old Tupperware parties of the past. Along the way, it’s made tons of money for Allergan, the maker of Botox.

Perlane is similar to Cosmetic Tissue Augmentation Product (CTAP) by Anika Therapeutics, Inc. which is another hyaluronic acid product for wrinkle reduction which was passed by the FDA in December of 2006.

What is it? Perlane is composed of transparent, viscous gel particles of hyaluronic acid that are implanted into facial tissue to provide volume in or just under the skin to smooth wrinkles and folds, especially around the nose, mouth and under the edges of the mouth (nasolabial folds and oral commissures). Hyaluronic acid is a protective, lubricating and water-binding substance that is produced naturally by the body.  Hyaluronic acid has been used in the past in a brand name product called Synvisc which injects hyaluronic acid into the joints to act as a viscous layer to treat osteoarthritis.

How does it work? Perlane works by temporarily adding volume to facial tissue and restoring a smoother appearance to the face

When is it used? Perlane is injected by a doctor into areas of facial tissue where moderate to severe facial wrinkles and folds occur as a result of loss of underlying volume. The gel particles temporarily add volume in and under the skin to restore surface contour and give the skin a smoother and more youthful appearance.

What will it accomplish? Perlane will help smooth moderate to severe facial wrinkles and folds. In two clinical studies, 89% of the Perlane patients achieved optimal correction of midface volume loss that caused their wrinkles and fold (nasolabial folds and oral commissures). The surface contour improvement lasted for at least 6 months.

Patients who have used both Perlane and Collagen see that Perlane lasts about twice as long as the latter. With the success of Botox, multiple other pharmaceutical companies have outpatient cosmetic devices to help make the decision a bit more difficult for doctors. As we talk three more products in are final review with the FDA and with baby boomers getting older plus the advent of twenty-something youths using products like Botox, it looks like there will be plenty of consumers to go around.

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